The cornea consists primarily of three layers: an outer layer containing an epithelium, a
middle stromal layer consisting of a collagen-rich extracellular matrix (ECM) interspersed …

Corneal transplantation is the most successful solid organ transplantation performed in
humans. The extraordinary success of orthotopic corneal allografts, in both humans and …

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

The cornea and the skin are both organs that provide the outer barrier of the body. Both
tissues have developed intrinsic mechanisms that protect the organism from a wide range of …

The cornea is a special interface between the internal ocular tissue and the external
environment that provides a powerful chemical, physical, and biological barrier against the …

Similar to the brain, the eye is considered an immune‐privileged organ where tissue‐
resident macrophages provide the major immune cell constituents. However, little is known …

Angiogenesis, the process of new blood vessel formation from existing blood vessels, is a
key aspect of virtually every repair process. During wound healing an extensive, but …

The cornea is one of the few tissues which actively maintain an avascular state, ie the
absence of blood and lymphatic vessels (corneal [lymph] angiogenic privilege). Nonetheless …

The eye and the brain are immunologically privileged sites, a property previously attributed
to the lack of a lymphatic circulation. However, recent tracking studies confirm that these …

Aspergillus species are a major worldwide cause of corneal ulcers, resulting in visual
impairment and blindness in immunocompetent individuals. To enhance our understanding …