Acetylcholine receptors were initially defined as nicotinic or muscarinic, based on selective
activation by two natural products, nicotine and muscarine. Several further nicotinic agonists …

Discovery of the important role played by nicotinic acetylcholine receptors (nAChRs) in
several CNS disorders has called attention to these membrane proteins and to ligands able …

A highly efficient asymmetric hydrogenation of cyclic imines containing a pyridyl moiety was
established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. This …

In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important
targets for drug discovery. The therapeutic potential of nicotinic agonists depends …

Agonists of the a4b2 nicotinic acetylcholine receptors have been synthesised as potential
drugs for treatment of a variety of diseases. In this review, the published nicotinic agonists …

Cytisine (cy) is a potent and competitive partial agonist at α4 subunit-containing nicotinic
acetylcholine (nACh) receptors while at homomeric α7-nACh receptors it behaves as a full …

The gas-phase basicities (GBs) of nornicotine, nicotine, and model pyrrolidines have been
measured by FT-ICR. These experimental GBs are compared with those calculated (for the …

Multiple populations of pentameric nicotinic acetylcholinergic (nACh) receptors exist and
several may be classified as central or neuronal. Neuronal nACh receptors, however, are …

Effects of cytisine (cy), 3‐bromocytisine (3‐Br‐cy), 5‐bromocytisine (5‐Br‐cy) and 3, 5‐
dibromocytisine (3, 5‐diBr‐cy) on human (h) α7‐, α4β2‐and α4β4 nicotinic acetylcholine …

A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors
(nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of bridged bicyclic …