Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications

F Steffen-Munsberg, C Vickers, H Kohls, H Land… - Biotechnology …, 2015 - Elsevier
In this review we analyse structure/sequence–function relationships for the superfamily of
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis

TS Kang, D Georgieva, N Genov… - The FEBS …, 2011 - Wiley Online Library
Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the
immobilization and digestion of prey. The most common snake venom enzymes include …

Automated comparative protein structure modeling with SWISS‐MODEL and Swiss‐PdbViewer: A historical perspective

N Guex, MC Peitsch, T Schwede - Electrophoresis, 2009 - Wiley Online Library
SWISS‐MODEL pioneered the field of automated modeling as the first protein modeling
service on the Internet. In combination with the visualization tool Swiss‐PdbViewer, the …

Peptidebert: A language model based on transformers for peptide property prediction

C Guntuboina, A Das, P Mollaei, S Kim… - The Journal of …, 2023 - ACS Publications
Recent advances in language models have enabled the protein modeling community with a
powerful tool that uses transformers to represent protein sequences as text. This …

IC 50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

RZ Cer, U Mudunuri, R Stephens… - Nucleic acids …, 2009 - academic.oup.com
A new web-server tool estimates K i values from experimentally determined IC 50 values for
inhibitors of enzymes and of binding reactions between macromolecules (eg proteins …

PROSO II–a new method for protein solubility prediction

P Smialowski, G Doose, P Torkler… - The FEBS …, 2012 - Wiley Online Library
Many fields of science and industry depend on efficient production of active protein using
heterologous expression in Escherichia coli. The solubility of proteins upon expression is …

[HTML][HTML] Outcome of the first wwPDB hybrid/integrative methods task force workshop

A Sali, HM Berman, T Schwede, J Trewhella… - Structure, 2015 - cell.com
Structures of biomolecular systems are increasingly computed by integrative modeling that
relies on varied types of experimental data and theoretical information. We describe here the …

[HTML][HTML] DSResSol: A sequence-based solubility predictor created with Dilated Squeeze Excitation Residual Networks

M Madani, K Lin, A Tarakanova - International Journal of Molecular …, 2021 - mdpi.com
Protein solubility is an important thermodynamic parameter that is critical for the
characterization of a protein's function, and a key determinant for the production yield of a …

Automated protein structure modeling with SWISS-MODEL Workspace and the Protein Model Portal

L Bordoli, T Schwede - Homology Modeling: Methods and Protocols, 2012 - Springer
Comparative protein structure modeling is a computational approach to build three-
dimensional structural models for proteins using experimental structures of related protein …

Pre-training of deep bidirectional protein sequence representations with structural information

S Min, S Park, S Kim, HS Choi, B Lee, S Yoon - IEEE Access, 2021 - ieeexplore.ieee.org
Bridging the exponentially growing gap between the numbers of unlabeled and labeled
protein sequences, several studies adopted semi-supervised learning for protein sequence …