Mechanisms of lncRNA/microRNA interactions in angiogenesis

Z Zhao, W Sun, Z Guo, J Zhang, H Yu, B Liu - Life sciences, 2020 - Elsevier
Angiogenesis is a complex physiological process. However, over the past couple of
decades, abnormally accelerated or pathological angiogenesis has garnered greater …

The complex role of MEG3: an emerging long non-coding RNA in breast cancer

MS Hussain, AA Majami, H Ali, G Gupta… - … -Research and Practice, 2023 - Elsevier
MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse
biological processes, particularly breast cancer (BC) development. Within the imprinting …

Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis

J Liang, Q Wang, JQ Li, T Guo, D Yu - Experimental neurology, 2020 - Elsevier
Objective Inflammasome contributes to ischemic brain injury by inducing pyroptosis and
inflammation. The aim of this study is to unravel the mechanism of long non-coding RNA …

[HTML][HTML] Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA

S Ghafouri-Fard, M Taheri - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Abstract Maternally expressed gene 3 (MEG3) is a long non-coding RNA (lncRNA) located
on chromosome 14q32. 3. Direct sequencing experiments have shown monoallelic …

LncRNA MEG3 regulates the interplay between Th17 and Treg cells in Behçet's disease and systemic lupus erythematosus

NA Mehana, HR Ghaiad, M Hassan, YA Elsabagh… - Life Sciences, 2022 - Elsevier
Background Behçet's disease (BD) and systemic lupus erythematosus (SLE) are two
autoimmune inflammatory diseases of indefinite etiology. However, up till now, no study has …

Long non-coding RNAs and JAK/STAT signaling pathway regulation in colorectal cancer development

A Ghasemian, HA Omear, Y Mansoori… - Frontiers in …, 2023 - frontiersin.org
Colorectal cancer (CRC) is one of the main fatal cancers. Cell signaling such as Janus
kinase/signal transducer and activator of transcription (JAK/STAT) signaling substantially …

The biological roles and molecular mechanisms of long non-coding RNA MEG3 in the hallmarks of cancer

L Zhang, F Zhao, W Li, G Song, V Kasim, S Wu - Cancers, 2022 - mdpi.com
Simple Summary MEG3 is a class of lncRNA, which is considered a tumor suppressor. It is
lost or decreased in different biological processes of various human tumors and is closely …

LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases

Z Li, J Gao, D Sun, Q Jiao, J Ma, W Cui, Y Lou… - Frontiers in …, 2022 - frontiersin.org
The prevalence and mortality rates of cardiovascular diseases are increasing, and new
treatment strategies are urgently needed. From the perspective of basic pathogenesis, the …

Crosstalk between Long non coding RNAs, microRNAs and DNA damage repair in prostate cancer: new therapeutic opportunities?

F Orafidiya, L Deng, CL Bevan, CE Fletcher - Cancers, 2022 - mdpi.com
Simple Summary Non-coding RNAs are a type of genetic material that doesn't make protein,
but performs diverse regulatory functions. In prostate cancer, most treatments target proteins …

Recent progress and the emerging role of lncRNAs in cancer drug resistance; focusing on signaling pathways

MJ Saadh, I Rasulova, MAA Almoyad… - … -Research and Practice, 2024 - Elsevier
It is becoming more and more apparent that many of the genetic alterations associated with
cancer are located in areas that do not encode proteins. lncRNAs are a class of RNAs that …