The chondroitinases (Chase) are bacterial lyases that specifically digest chondroitin sulfate
and/or dermatan sulfate glycosaminoglycans via a β-elimination reaction and generate …

Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC
(ChABC) has shown promise in central nervous system (CNS) regeneration, yet its …

Thermodynamics of protein folding refers to the stability measurements where structural
changes of a given protein in the presence of a denaturing agent are monitored by …

Chondroitin sulfate (CS) is a sulfated glycosaminoglycan with diverse biological activities,
which are influenced by molecular weight (Mw) and sulfation pattern. In the present work, we …

Determining the influence of tissue composition on the osmotic swelling stress of articular
cartilage and meniscus fibrocartilage is important to enhance our understanding of …

Although synonymous mutations have long been thought to lack striking results, a growing
body of research shows these mutations have highly variable effects. In this study, the …

Abstract Chondroitinase ABC I (cABC I) can degrade inhibitory molecules for axon regrowth
at the site of damage after spinal cord injury (SCI). One of the main problems in the practical …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are the main inhibitors for axon
regeneration after damaging of Central Nervous System (CNS). Chondroitinase ABC I …

Regarding the existence of similar helices on the structure of different proteins, recently,
novel variants of Chondroitinase ABC I (cABC I) have been constructed, where a …

Abstract Chondroitinase ABC I (cABC I) from Proteus vulgaris is an important enzyme in
medicinal biotechnology due to its ability to help axon regeneration after spinal cord injury …