Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

As the most apical structure between epithelial and endothelial cells, tight junctions (TJ) are
well known as functioning as a control for the paracellular diffusion of ions and certain …

Patients with inflammatory bowel disease (IBD) are at increased risk of developing
colorectal adenocarcinoma. The factors that result in IBD-associated carcinogenesis are not …

Claudins are major integral membrane proteins of tight junctions. Altered expression of
several claudin proteins, in particular claudin-1,-3,-4 and-7, has been linked to the …

Claudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and
cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic …

Tight junctions are the apical cell‐cell adhesion that regulate paracellular permeability and
are critical for epithelial cell polarity. Molecular architecture of tight junction has been studied …

Members of the claudin protein family are key regulators of tight junction selectivity and are
implicated in influencing development and cellular differentiation in the intestine and other …

Tight junctions, or zonula occludens, are the most apical component of the junctional
complex and provide one form of cell–cell adhesion in epithelial and endothelial cells …

The claudin family, in mammals, encoded by at least 27 members of a single ancestral gene,
CLDN, is the main constituent as integral membrane proteins of tight junctions. It has been …

Claudins, members of a large family of adherent junction proteins, regulate the integrity and
function of tight junctions and influence tumorigenesis. Recent studies have shown that …