Recent progress in understanding the molecular basis of cellular processes, identification of
promising therapeutic targets and evolution of the regulatory landscape makes this an …

Colorectal cancer (CRC) is a serious disease that affects millions of people throughout the
world, despite considerable advances in therapy. The formation of colorectal adenomas and …

The majority of metastatic colorectal cancers (mCRC) are mismatch repair (MMR) proficient
and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond …

The RAS oncogene is among the most commonly mutated in cancer. RAS mutations are
identified in about half of patients diagnosed with metastatic colorectal cancer (mCRC) …

Over the last decade, there have been improvements in colorectal cancer (CRC) incidence
and survival. 1–5 These outcomes are attributed to multidisciplinary advances, including the …

The revolution of precision medicine has produced unprecedented seismic shifts in the
treatment paradigm of advanced cancers. Among the major killers, colorectal cancer (CRC) …

Background WNT974 is a small molecule inhibitor of Wnt signaling that specifically inhibits
porcupine O-acyltransferase. This phase Ib dose-escalation study evaluated the maximum …

Simple Summary A subset of colorectal cancers (CRCs) is characterized by a mismatch
repair deficiency that is frequently associated with microsatellite instability (MSI). The …

Objective To investigate the relationship among 18 heavy metals, microsatellite instability
(MSI) status, ERCC1, XRCC1 (rs25487), BRAF V600E and 5 tumor markers and their role in …

As the third most severe cancer in the world, colorectal cancer (CRC) is of high concern to
global health concerns. Aging, unhealthy lifestyles, and genetic factors contribute to CRC …