Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
Paving the way to single-molecule protein sequencing
Proteins are major building blocks of life. The protein content of a cell and an organism
provides key information for the understanding of biological processes and disease. Despite …
provides key information for the understanding of biological processes and disease. Despite …
[HTML][HTML] A quantitative proteome map of the human body
Determining protein levels in each tissue and how they compare with RNA levels is
important for understanding human biology and disease as well as regulatory processes …
important for understanding human biology and disease as well as regulatory processes …
A high-stringency blueprint of the human proteome
Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project
(HPP) in 2010, creating an international framework for global collaboration, data sharing …
(HPP) in 2010, creating an international framework for global collaboration, data sharing …
A pan-plant protein complex map reveals deep conservation and novel assemblies
Plants are foundational for global ecological and economic systems, but most plant proteins
remain uncharacterized. Protein interaction networks often suggest protein functions and …
remain uncharacterized. Protein interaction networks often suggest protein functions and …
Building ProteomeTools based on a complete synthetic human proteome
We describe ProteomeTools, a project building molecular and digital tools from the human
proteome to facilitate biomedical research. Here we report the generation and multimodal …
proteome to facilitate biomedical research. Here we report the generation and multimodal …
Missing data in multi-omics integration: Recent advances through artificial intelligence
JE Flores, DM Claborne, ZD Weller… - Frontiers in Artificial …, 2023 - frontiersin.org
Biological systems function through complex interactions between various 'omics
(biomolecules), and a more complete understanding of these systems is only possible …
(biomolecules), and a more complete understanding of these systems is only possible …
Mass spectrometry–based protein identification in proteomics—a review
Statistically, accurate protein identification is a fundamental cornerstone of proteomics and
underpins the understanding and application of this technology across all elements of …
underpins the understanding and application of this technology across all elements of …
Protein biomarkers for subtyping breast cancer and implications for future research
Introduction: Breast cancer subtypes are currently defined by a combination of morphologic,
genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the …
genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the …
PepQuery2 democratizes public MS proteomics data for rapid peptide searching
We present PepQuery2, which leverages a new tandem mass spectrometry (MS/MS) data
indexing approach to enable ultrafast, targeted identification of novel and known peptides in …
indexing approach to enable ultrafast, targeted identification of novel and known peptides in …