Over the past few years, substantial advances have been made in understanding the
pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and …

The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …

Background Advanced systemic mastocytosis comprises rare hematologic neoplasms that
are associated with a poor prognosis and lack effective treatment options. The multikinase …

This is the fourth iteration of this parameter entitled “The Diagnosis and Management of
Anaphylaxis.” The first anaphylaxis parameter was published in 1998 and the last in 2010 …

Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the
pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to …

Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the
expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The …

Overview Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast
cells (MCs) in extra‐cutaneous organs. Diagnosis The major criterion is presence of …

Purpose To analyze the prognostic impact of mutated KIT (mut KIT) in core-binding factor
acute myeloid leukemia (AML) with inv (16)(p13q22) and t (8; 21)(q22; q22). Patients and …

Mast cells have been recognized for well over 100 years. With time, human mast cells have
been documented to originate from CD34+ cells, and have been implicated in host …

Midostaurin was a prototype kinase inhibitor, originally developed as a protein kinase C
inhibitor and subsequently as an angiogenesis inhibitor, based on its inhibition of vascular …