Do current measures of polygenic risk for mental disorders contribute to population variance in mental health?
A Marsman, LK Pries, M Ten Have… - Schizophrenia …, 2020 - academic.oup.com
The polygenic risk score (PRS) allows for quantification of the relative contributions of genes
and environment in population-based studies of mental health. We analyzed the impact of …
and environment in population-based studies of mental health. We analyzed the impact of …
Polygenic risk scores shed light on the relationship between schizophrenia and cognitive functioning: review and meta-analysis
Schizophrenia is a multifactorial disease associated with widespread cognitive impairment.
Although cognitive deficits are one of the factors most strongly associated with functional …
Although cognitive deficits are one of the factors most strongly associated with functional …
Schizophrenia: a developmental disorder with a risk of non-specific but avoidable decline
The onset of schizophrenia is determined by biological and social risk factors operating
predominantly during development. These result in subtle deviations in brain structure and …
predominantly during development. These result in subtle deviations in brain structure and …
Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum
AimsPsychosis spectrum disorder has a complex pathoetiology characterised by interacting
environmental and genetic vulnerabilities. The present study aims to investigate the role of …
environmental and genetic vulnerabilities. The present study aims to investigate the role of …
Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia
Importance Both adulthood stressful life events (SLEs) and liability for schizophrenia have
been associated with poor mental and physical health in the general population, but their …
been associated with poor mental and physical health in the general population, but their …
Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness
LK Pries, B Klingenberg… - Acta Psychiatrica …, 2020 - Wiley Online Library
Objective To test whether polygenic risk score for schizophrenia (PRS‐S) interacts with
childhood adversity and daily‐life stressors to influence momentary mental state domains …
childhood adversity and daily‐life stressors to influence momentary mental state domains …
Childhood abuse v. neglect and risk for major psychiatric disorders
A Alkema, M Marchi, JAJ Van Der Zaag… - Psychological …, 2024 - cambridge.org
BackgroundChildhood maltreatment (CM) is a strong risk factor for psychiatric disorders but
serves in its current definitions as an umbrella for various fundamentally different childhood …
serves in its current definitions as an umbrella for various fundamentally different childhood …
Analysis of GWAS-derived schizophrenia genes for links to ischemia-hypoxia response of the brain
R Schmidt-Kastner, S Guloksuz, T Kietzmann… - Frontiers in …, 2020 - frontiersin.org
Obstetric complications (OCs) can induce major adverse conditions for early brain
development and predispose to mental disorders, including schizophrenia (SCZ). We …
development and predispose to mental disorders, including schizophrenia (SCZ). We …
Predictive performance of exposome score for schizophrenia in the general population
Previously, we established an estimated exposome score for schizophrenia (ES-SCZ) as a
cumulative measure of environmental liability for schizophrenia to use in gene–environment …
cumulative measure of environmental liability for schizophrenia to use in gene–environment …
The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
L Sideli, M Aas, D Quattrone, D La Barbera… - Social psychiatry and …, 2023 - Springer
This study investigated if the association between childhood maltreatment and cognition
among psychosis patients and community controls was partially accounted for by genetic …
among psychosis patients and community controls was partially accounted for by genetic …