Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune …

Individuals with Behçet's disease suffer from episodic inflammation often affecting the
orogenital mucosa, skin and eyes. To discover new susceptibility loci for Behçet's disease …

In the past decade, there have been fundamental advances in our understanding of genetic
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …

Our understanding of the genetic basis of systemic lupus erythematosus (SLE) has been
rapidly advanced using large-scale, case–control, candidate gene studies as well as …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with manifold
clinical manifestations and immunological abnormalities, affecting primarily women …

Lupus nephritis remains one of the most severe manifestations of systemic lupus
erythematosus associated with considerable morbidity and mortality. A better understanding …

Infections are known to trigger flares of autoimmune diseases in humans and serve as an
inciting cause of autoimmunity in animals. Evidence suggests a causative role of infections …

The genome-wide association study is a free-hypothesis approach based on screening of
thousands or even millions of genetic variants distributed throughout the whole human …

Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple
sclerosis and inflammatory bowel disease, have complex pathogeneses and likely …