As the key cellular effectors of adaptive immunity, T and B lymphocytes utilize specialized
receptors to recognize, respond to, and neutralize a diverse array of extrinsic threats. These …

Abstract γδ T cells constitute a sizeable and non-redundant fraction of the total T cell pool in
all jawed vertebrates, but in contrast to conventional αβ T cells they are not restricted by …

The T cell receptor (TCR) protein is a heterodimer composed of an α chain and a β chain.
TCR genes undergo somatic DNA rearrangements to generate the diversity of T cell binding …

Early diagnosis of cutaneous T cell lymphoma (CTCL) is difficult and takes on average 6
years after presentation, in part because the clinical appearance and histopathology of …

Accumulating evidence suggests that the mouse embryonic thymus produces distinct waves
of innate effector γδ T cells. However, it is unclear whether this process occurs similarly in …

High-throughput sequencing (HTS) of lymphoid receptor genes is an emerging technology
that can comprehensively assess the diversity of the immune system. Here, we applied HTS …

The role of γδ T cells in antitumor immunity has been under investigation for the past two
decades, but little is known about their contribution to clinical outcomes in patients. Here, we …

Whereas pathogen-specific T and B cells are a primary focus of interest during infectious
disease, we have used COVID-19 to ask whether their emergence comes at a cost of …

Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface
of B and T cells. The final set of these molecules in each organism is formed under the …

The adaptive immune system relies on the diversity of receptors expressed on the surface of
B-and T cells to protect the organism from a vast amount of pathogenic threats. The …