The intrinsic electrical characteristics of different types of neurons are shaped by the K+
channels they express. From among the more than 70 different K+ channel genes …

Ion channels are vital contributors to cellular communication in a wide range of organisms, a
distinct feature that renders this ubiquitous family of membrane-spanning proteins a prime …

Cannabidiol (CBD), a major non-psychoactive phytocannabinoid in cannabis, is an effective
treatment for some forms of epilepsy and pain. At high concentrations, CBD interacts with a …

Kv2 family “delayed-rectifier” potassium channels are widely expressed in mammalian
neurons. Kv2 channels activate relatively slowly and their contribution to action potential …

Sea anemones have been understudied as a source of peptide and protein toxins, with
relatively few examined as a source of new pharmacological tools or therapeutic leads. This …

Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different
molecular scaffolds reported to date. These venom components have traditionally been …

This article provides a brief overview of the literature related to the chemical ecology of sea
anemones, focusing on their venom, and summarizing their bioprospecting potential. Sea …

Voltage-gated potassium channels play a key role in human physiology and pathology.
Reflecting their importance, numerous channelopathies have been characterised that arise …

APETx3, a novel peptide isolated from the sea anemone Anthopleura elegantissima, is a
naturally occurring mutant from APETx1, only differing by a Thr to Pro substitution at position …

Toxins from marine animals provide molecular tools for the study of many ion channels,
including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity …