High-resolution human KIR genotyping
J Downing, L D'Orsogna - Immunogenetics, 2022 - Springer
Killer immunoglobulin-like receptors (KIR) regulate the function of natural killer cells through
interactions with various ligands on the surface of cells, thereby determining whether natural …
interactions with various ligands on the surface of cells, thereby determining whether natural …
Breaking down barriers: The potential of smarter CAR‐engineered NK cells against solid tumors
Natural killer (NK) cells are considered to be the foremost fighters of our innate immune
system against foreign invaders and thus tend to promptly latch onto the virus‐infected and …
system against foreign invaders and thus tend to promptly latch onto the virus‐infected and …
IGSF8 is an innate immune checkpoint and cancer immunotherapy target
Y Li, X Wu, C Sheng, H Liu, H Liu, Y Tang, C Liu… - Cell, 2024 - cell.com
Antigen presentation defects in tumors are prevalent mechanisms of adaptive immune
evasion and resistance to cancer immunotherapy, whereas how tumors evade innate …
evasion and resistance to cancer immunotherapy, whereas how tumors evade innate …
Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health
NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
Full resolution HLA and KIR gene annotations for human genome assemblies
The Human leukocyte antigens (HLA) genes and the Killer cell immunoglobulin like
receptors (KIR) genes are critical to immune responses and are associated with many …
receptors (KIR) genes are critical to immune responses and are associated with many …
HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis
V Peris Sempere, G Luo, S Muñiz-Castrillo… - Frontiers in …, 2024 - frontiersin.org
Introduction Genetic predisposition to autoimmune encephalitis with antibodies against N-
methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of …
methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of …
Genetic complexity of killer-cell immunoglobulin-like receptor genes in human pangenome assemblies
TK Hung, WC Liu, SK Lai, HW Chuang… - Genome …, 2024 - genome.cshlp.org
The killer-cell immunoglobulin-like receptor (KIR) gene complex, a highly polymorphic
region of the human genome that encodes proteins involved in immune responses, poses …
region of the human genome that encodes proteins involved in immune responses, poses …
Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders, representing high
risk of progression to acute myeloid leukaemia, and frequently associated to somatic …
risk of progression to acute myeloid leukaemia, and frequently associated to somatic …
Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region
L de Brito Vargas, MH Beltrame, B Ho… - Molecular biology …, 2022 - academic.oup.com
The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen
(HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells …
(HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells …
[HTML][HTML] An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania
Genetic variation in host immunity impacts the disproportionate burden of infectious
diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte …
diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte …