Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
Inflammatory cytokines and chemokines as therapeutic targets in heart failure
A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …
suggests that regardless of the underlying etiology, heart failure is associated with induction …
Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study
Background Mortality of patients with coronavirus disease 2019 (COVID-19), acute
respiratory distress syndrome (ARDS), and systemic inflammation is high. In areas of …
respiratory distress syndrome (ARDS), and systemic inflammation is high. In areas of …
Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
Targeting early atherosclerosis: a focus on oxidative stress and inflammation
P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …
Inflammation in Heart Failure: JACC State-of-the-Art Review
It has long been observed that heart failure (HF) is associated with measures of systemic
inflammation. In recent years, there have been significant advancements in our …
inflammation. In recent years, there have been significant advancements in our …
Coronary microvascular dysfunction
F Vancheri, G Longo, S Vancheri, M Henein - Journal of Clinical …, 2020 - mdpi.com
Many patients with chest pain undergoing coronary angiography do not show significant
obstructive coronary lesions. A substantial proportion of these patients have abnormalities in …
obstructive coronary lesions. A substantial proportion of these patients have abnormalities in …
[HTML][HTML] Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases
Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
[HTML][HTML] Cardiac fibrosis: new insights into the pathogenesis
ZG Ma, YP Yuan, HM Wu, X Zhang… - International journal of …, 2018 - ncbi.nlm.nih.gov
Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …