Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …

Abstract The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the
regulation of numerous biological processes including development of the immune system …

The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a …

Selective autophagy specifically eliminates damaged or superfluous organelles, maintaining
cellular health. In this process, a double membrane structure termed an autophagosome …

NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …

Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains
of some proteins are almost invariant in sequence and length, betraying a structural and …

Ubiquitylation is one of the most abundant and versatile post-translational modifications
(PTMs) in cells. Its versatility arises from the ability of ubiquitin to form eight structurally and …

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

Modification by Lys63-linked ubiquitin (UbK63) chains is the second most abundant form of
ubiquitylation. In addition to their role in DNA repair or kinase activation, UbK63 chains …

A large body of literature describes elaborate NF-κB signaling networks induced by
inflammatory and immune signals. Decades of research has revealed that transcriptionally …