Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions
SH Francis, MA Blount, JD Corbin - Physiological reviews, 2011 - journals.physiology.org
The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5
RH Cote - International journal of impotence research, 2004 - nature.com
Abstract Phosphodiesterase 6 (PDE6) is highly concentrated in the retina. It is most
abundant in the internal membranes of retinal photoreceptors, where it reduces cytoplasmic …
abundant in the internal membranes of retinal photoreceptors, where it reduces cytoplasmic …
The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors
W Baehr, S Karan, T Maeda, DG Luo, S Li… - Journal of Biological …, 2007 - ASBMB
Retinal guanylate cyclases 1 and 2 (GC1 and GC2) are responsible for synthesis of cyclic
GMP in rods and cones, but their individual contributions to phototransduction are unknown …
GMP in rods and cones, but their individual contributions to phototransduction are unknown …
[HTML][HTML] GAF domains: Two–billion–year–old molecular switches that bind cyclic nucleotides
SE Martinez, JA Beavo… - Molecular …, 2002 - triggered.edina.clockss.org
GAF domains represent one of the largest families of small-molecule binding units present in
nature. The first mammalian GAF domains discovered were the cGMP-binding regulatory …
nature. The first mammalian GAF domains discovered were the cGMP-binding regulatory …
[图书][B] Cyclic nucleotide phosphodiesterases in health and disease
J Beavo, SH Francis, MD Houslay - 2007 - api.taylorfrancis.com
The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …
cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11
M Gross-Langenhoff, K Hofbauer, J Weber… - Journal of Biological …, 2006 - ASBMB
N-terminal tandem GAF domains are present in 5 out of 11 mammalian phosphodiesterase
(PDE) families. The ligand for the GAF domains of PDEs 2, 5, and 6 is cGMP, whereas those …
(PDE) families. The ligand for the GAF domains of PDEs 2, 5, and 6 is cGMP, whereas those …
[HTML][HTML] Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors
X Zhang, Q Feng, RH Cote - Investigative ophthalmology & visual …, 2005 - arvojournals.org
purpose. Phosphodiesterase (PDE) inhibitors are important therapeutic agents, but their
effects on photoreceptor PDE (PDE6) and photoreceptor cells are poorly understood. The …
effects on photoreceptor PDE (PDE6) and photoreceptor cells are poorly understood. The …
[HTML][HTML] The history and role of naturally occurring mouse models with Pde6b mutations
J Han, A Dinculescu, X Dai, W Du, WC Smith… - Molecular …, 2013 - ncbi.nlm.nih.gov
Mouse models are useful tools for developing potential therapies for human inherited retinal
diseases, such as retinitis pigmentosa (RP), since more strains are being identified with the …
diseases, such as retinitis pigmentosa (RP), since more strains are being identified with the …
AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase
X Liu, OV Bulgakov, XH Wen… - Proceedings of the …, 2004 - National Acad Sciences
Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) is a member of the FK-506-
binding protein family expressed specifically in retinal photoreceptors. Mutations in AIPL1 …
binding protein family expressed specifically in retinal photoreceptors. Mutations in AIPL1 …
Photoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones
RH Cote - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
Rod and cone photoreceptors of the vertebrate retina utilize cGMP as the primary
intracellular messenger for the visual signaling pathway that converts a light stimulus into an …
intracellular messenger for the visual signaling pathway that converts a light stimulus into an …