Since its first description more than 20 years ago osteopontin has emerged as an active
player in many physiological and pathological processes, including biomineralization, tissue …

As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …

Diabetic kidney disease (DKD) occurs in∼ 40% of patients with diabetes and causes kidney
failure, cardiovascular disease, and premature death. We analyzed the response of a …

Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

Proteinuria is a major health-care problem that affects several hundred million people
worldwide. Proteinuria is a cardinal sign and a prognostic marker of kidney disease, and …

Alport syndrome (AS) is a hereditary kidney disease associated with proteinuria, hematuria
and progressive kidney failure. It is characterized by a defective glomerular basement …

Diabetic kidney disease (DKD) is the single most common cause of albuminuria and end-
stage kidney disease in the United States. We found increased expression of Wnt/β-catenin …

An intact kidney filter is vital to retention of essential proteins in the blood and removal of
waste from the body. Damage to the filtration barrier results in albumin loss in the urine, a …

Approximately a third of patients with diabetes develop diabetic kidney disease, and
diabetes is the leading cause of end-stage renal disease in most developed countries …