Prions are unprecedented infectious pathogens that cause a group of invariably fatal
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …

Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding
aggregates. Substantial data support the hypothesis that partially folded intermediates are …

The discovery of infectious proteins, denoted prions, was unexpected. After much debate
over the chemical basis of heredity, resolution of this issue began with the discovery that …

Variations in prions, which cause different incubation times and deposition patterns of the
prion protein isoform called PrP Sc, are often referred to as' strains'. We report here a highly …

Protein aggregation is an important phenomenon that alternatively is part of the normal
functioning of nature or, central to this review, has negative consequences via its …

The yeast non-Mendelian factor [psi+] has been suggested to be a self-modified protein
analogous to mammalian prions. Here it is reported that an intermediate amount of the …

We present a method to predict complex structural (conformational) transitions in irregular or
disordered macromolecular systems, such as proteins or glasses, at the atomic level. Our …

Prion Protein Biology: Cell Skip to Main Content Advertisement Cell This journal offers authors
two options (open access or subscription) to publish research Submit Log in Register Log in …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

The fundamental event in prion diseases seems to be a conformational change in cellular
prion protein (PrPC) whereby it is converted into the pathologic isoform PrPSc. In fatal …