Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

Receptor signaling relays on intracellular events amplified by secondary and tertiary
messenger molecules. In cardiomyocytes and smooth muscle cells, cyclic AMP (cAMP) and …

Peptides are highly selective and efficacious for the treatment of cardiovascular and other
diseases. However, it is currently not possible to administer peptides for cardiac-targeting …

Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease accompanied by structural
and contractile alterations. We identified a rare c. 740C> T (p. T247M) mutation in ACTN 2 …

Although ischemic heart disease is the major cause of death in diabetic patients, diabetic
cardiomyopathy (DCM) is increasingly recognized as a clinically relevant entity. Considering …

Background: Correct gene expression programming of the cardiomyocyte underlies the
normal functioning of the heart. Alterations to this can lead to the loss of cardiac …

The mitochondrial Ca2+ uniporter complex (MCUC) is a multimeric ion channel which, by
tuning Ca2+ influx into the mitochondrial matrix, finely regulates metabolic energy …

Myocardial infarction is one of the major causes of morbidity and mortality worldwide.
Current treatments can relieve the symptoms of myocardial ischemia but cannot repair the …

Diabetes mellitus affects the heart through various mechanisms such as microvascular
defects, metabolic abnormalities, autonomic dysfunction and incompatible immune …

Despite advances in care, cardiovascular diseases remain the leading cause of death
worldwide. As a result, identifying suitable biomarkers for early diagnosis and improving …