Driver mutations promote initiation and progression of cancer. Pharmacological treatment
can inhibit the action of the mutant protein; however, drug resistance almost invariably …

Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery.
However, cancers often develop resistance against drugs, leading to failure of treatment and …

Multidrug resistance is a key determinant of cancer chemotherapy failure. One of the major
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …

Indeed, multi-drug resistance (MDR) is a significant obstacle to effective chemotherapy. The
overexpression of ATP-binding cassette (ABC) membrane transporters is a principal cause …

1. INTRODUCTION The length of straightened-out DNA in a single cell is nearly 2 m. In
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …

Multidrug resistance (MDR) is a primary hindrance to curative cancer chemotherapy. In this
respect, lysosomes were suggested to play a role in intrinsic MDR by sequestering …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

ABCG2 was discovered in multi-drug-resistant cancer cells, with the identification of
chemotherapeutic agents, such as mitoxantrone, flavopiridol, methotrexate and irinotecan as …

Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has
been driving the search for more active and specific compounds. In this work, we show how …