Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …

All cells comprising the skeleton—chondrocytes, osteoblasts, and osteoclasts—contain both
the vitamin D receptor and the enzyme CYP27B1 required for producing the active …

Breast cancer is the most common cancer affecting women worldwide, with bone
metastases presenting as the most common site of disease recurrence. Bone metastases …

Fundamental to understanding the way in which perturbations in the vitamin D endocrine
system can affect human health is an appreciation of the steps involved in the production of …

Vitamin D deficiency continues to attract considerable attention because of claims that an
adequate status can reduce the risk of a wide range of diseases. The facts are that this …

Antiosteoporotic medications are often used to concurrently treat a patient's fragility fractures
and underlying osteoporosis. This review evaluates the existing literature from animal and …

Vitamin D (1, 25 (OH) 2D3) is a steroid hormone that has a range of physiological functions
in skeletal and nonskeletal tissues, and can contribute to prevent and/or treat osteoporosis …

Abstract Purpose of Review In addition to the actions of the endocrine hormone, 1alpha, 25-
dihydroxyvitamin D (1, 25 (OH) 2 D) in stimulating intestinal calcium absorption, the …

The extrarenal synthesis of 1α, 25 dihydroxyvitamin D3 (1, 25D) has been demonstrated in a
number of cell types including osteoblasts and cells of the monocyte/macrophage lineage …

Introduction Vitamin D is essential for bone mineralization and for the subsequent
maintenance of bone quality. Mineralization is part of hard callus formation and bone …