Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …

Psoriasis is now classified as an immune-mediated inflammatory disease (IMID) of the skin.
It is being recognized that patients with various IMIDs, including psoriasis, are at higher risk …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

Our population is ageing, and obesity is increasing in the elderly bringing massive and
rapidly changing burdens of ill health related to increased body weights and fat as well as …

Excessive monocyte activation with the development of excessive or uncontrolled release of
proinflammatory cytokines often results in host tissue injury and even death in patients with …

Adipose tissue is still regarded as a principle site for lipid storage and mobilizing tissue with
an important role in the control of energy homeostasis. Additionally, adipose tissue-secreted …

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …

The scientific interest in the biology of white adipose tissue (WAT) has increased since the
discovery of leptin in 1994. The description of the product of the gene obese (ob) …

Lymphocytes require glucose uptake and metabolism for normal survival and function. The
signals that regulate the expression and localization of glucose transporter 1 (Glut1) to allow …

The past few years of research on leptin have provided important information on the link
between metabolism and immune homeostasis. Adipocytes influence not only the endocrine …