In 2012, we published guidelines summarizing and evaluating late 2011 evidence for
diagnosis and therapy of urea cycle disorders (UCDs). With 1: 35 000 estimated incidence …

Malignant cells exhibit metabolic changes, when compared to their normal counterparts,
owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has …

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Combination drugs are an important class of US FDA approved pharmaceuticals. These
drugs have been on a continuous growth trajectory since the first combination drugs were …

Most cancers depend on a high rate of aerobic glycolysis for their continued growth and
survival. Paradoxically, some cancer cell lines also display addiction to glutamine despite …

Urea cycle disorders (UCDs) are inborn errors of ammonia detoxification/arginine synthesis
due to defects affecting the catalysts of the Krebs-Henseleit cycle (five core enzymes, one …

Background The clinical presentation of patients with organic acidurias (OAD) and urea
cycle disorders (UCD) is variable; symptoms are often non‐specific. Aims/methods To …

Purpose This study investigated the effect of food additives, artificial sweeteners and
domestic hygiene products on the gut microbiome and fibre fermentation capacity. Methods …

Background The disease course and long-term outcome of patients with organic acidurias
(OAD) and urea cycle disorders (UCD) are incompletely understood. Aims To evaluate the …

Sodium benzoate and potassium sorbate are extremely useful agents for food and beverage
preservation, yet concerns remain over their complete safety. Benzoate can react with the …