Introduction Rheumatoid arthritis (RA), which affects nearly 1% of the world's population, is a
debilitating autoimmune disease. Bone erosion caused by periarticular osteopenia and …

Angiogenesis plays a key role in the pathological process of inflammation and invasion of
the synovium, and primarily drives the progression of rheumatoid arthritis (RA). Recent …

Abstract Bone tissue constitutes 15–20% of human body weight and plays a crucial role in
supporting the body, coordinating movement, regulating mineral homeostasis, and …

Tissue injury causes activation of mesenchymal lineage cells into wound-repairing
myofibroblasts (MFs), whose uncontrolled activity ultimately leads to fibrosis. Although this …

O-GlcNAcylation is a dynamic post-translational modification that diversifies the proteome.
Its dysregulation is associated with neurological disorders that impair cognitive function, and …

Objectives: S100A4 is a Damage Associated Molecular Pattern (DAMP) protein. S100A4 is
overexpressed in systemic sclerosis (SSc) patients and levels correlate with organ …

Glycans, either alone or in complex with glycan-binding proteins, are essential structures
that can regulate cell biology by mediating protein stability or receptor dimerization under …

The dynamic and reversible modification of nuclear and cytoplasmic proteins by O-
GlcNAcylation significantly impacts the function and dysfunction of the immune system. O …

O-GlcNAcylation, as a post-translational modification, can modulate cellular activities such
as kinase activity, transcription-translation, protein degradation, and insulin signaling by …

Abstract O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is
a critical post-translational modification (PTM) of cytoplasmic and nuclear proteins. O …