Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer.
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …

Impaired wound healing is one of the severe complications of diabetes. Macrophages have
been shown to play a vital role in wound healing. In different wound environments …

Postmenopausal osteoporosis, mainly caused by osteoclast-induced bone resorption, has
become a global public health burden. Natural compounds are emerging as potential …

Transcription factor NF-κB has been extensively studied for its varied roles in cancer
development since its initial characterization as a potent retroviral oncogene. It is now clear …

ABSTRACT CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important
roles in immunity and cancer. Complete CYLD ablation, truncation and expression of …

Drug resistance is a well-known phenomenon leading to a reduction in the effectiveness of
pharmaceutical treatments. Resistance to chemotherapeutic agents can involve various …

Background The accumulation of M1-polarized macrophages and excessive inflammation
are important in the pathogenesis of diabetic foot ulcer (DFU). However, the underlying …

Thymic tumors are a group of rare mediastinal malignancies that include three different
histological subtypes with completely different clinical behavior: the thymic carcinomas, the …

The development of inflammation is mutually affected with damaged DNA and the abnormal
expression of protein modification. Ubiquitination, a way of protein modification, plays a key …

Macrophages substantially influence the development, progression, and complications of
inflammation-driven diseases. Although numerous studies support the critical role of Notch …