[HTML][HTML] Causes and consequences of DNA single-strand breaks
KW Caldecott - Trends in Biochemical Sciences, 2024 - cell.com
DNA single-strand breaks (SSBs) are among the most common lesions arising in human
cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient …
cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient …
Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells
A Tomita, H Sasanuma, T Owa, Y Nakazawa… - Nature …, 2023 - nature.com
CRISPR/Cas9-mediated gene editing has great potential utility for treating genetic diseases.
However, its therapeutic applications are limited by unintended genomic alterations arising …
However, its therapeutic applications are limited by unintended genomic alterations arising …
Two-ended recombination at a Flp-nickase-broken replication fork
R Elango, NM Nilavar, AG Li, D Nguyen, E Rass… - Molecular Cell, 2025 - cell.com
Replication fork collision with a DNA nick can generate a one-ended break, fostering
genomic instability. The opposing fork's collision with the nick could form a second DNA end …
genomic instability. The opposing fork's collision with the nick could form a second DNA end …
Break-induced replication orchestrates resection-dependent template switching
Break-induced telomere synthesis (BITS) is a RAD51-independent form of break-induced
replication that contributes to alternative lengthening of telomeres,. This homology-directed …
replication that contributes to alternative lengthening of telomeres,. This homology-directed …
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT
In some types of cancer, telomere length is maintained by the alternative lengthening of
telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation …
telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation …
TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans
C Manzato, L Larini, C Oss Pegorar… - Nucleic Acids …, 2023 - academic.oup.com
Several aspects of telomere biology are regulated by the telomeric repeat-containing RNA
TERRA. While TERRA expression is conserved through evolution, species-specific …
TERRA. While TERRA expression is conserved through evolution, species-specific …
53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR)
Break-induced replication (BIR) is mutagenic, and thus its use requires tight regulation, yet
the underlying mechanisms remain elusive. Here we uncover an important role of 53BP1 in …
the underlying mechanisms remain elusive. Here we uncover an important role of 53BP1 in …
Stressed? Break-induced replication comes to the rescue!
RS Lee, JM Twarowski, A Malkova - DNA repair, 2024 - Elsevier
Break-induced replication (BIR) is a homologous recombination (HR) pathway that repairs
one-ended DNA double-strand breaks (DSBs), which can result from replication fork …
one-ended DNA double-strand breaks (DSBs), which can result from replication fork …
The safe path at the fork: ensuring replication-associated DNA double-strand breaks are repaired by homologous recombination
JA Nickoloff, N Sharma, L Taylor, SJ Allen… - Frontiers in …, 2021 - frontiersin.org
Cells must replicate and segregate their DNA to daughter cells accurately to maintain
genome stability and prevent cancer. DNA replication is usually fast and accurate, with …
genome stability and prevent cancer. DNA replication is usually fast and accurate, with …