To ensure tissue homeostasis the brain needs to be protected from blood-derived
fluctuations or pathogens that could affect its function. Therefore, the brain capillaries …

Pulmonary arterial hypertension (PAH) is characterized by an important occlusive vascular
remodeling with the production of new endothelial cells, smooth muscle cells …

Canonical Wnt signaling is crucial for vascularization of the central nervous system and
blood-brain barrier (BBB) formation. BBB formation and modulation are not only important …

Vascular endothelial cells exhibit substantial phenotypic and transcriptional heterogeneity
which is established during early embryogenesis. However, the molecular mechanisms …

Zebrafish can achieve scar-free healing of heart injuries, and robustly replace all
cardiomyocytes lost to injury via dedifferentiation and proliferation of mature cardiomyocytes …

Abstract Development, growth, and remodeling of blood vessels occur through an intricate
process involving cell differentiation, proliferation, and rearrangement by cell migration …

Endothelial cells (ECs) line blood vessels and serve as a niche for hematopoietic stem and
progenitor cells (HSPCs). Recent data point to tissue-specific EC specialization as well as …

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord
injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells; a …

TG2 is a multifunctional enzyme involved in several cellular processes and has emerging as
a potential regulator of gene expression. In this regard, we have recently shown that TG2 is …

Vasculopathy is a pathological process occurring in the blood vessel wall, which could affect
the haemostasis and physiological functions of all the vital tissues/organs and is one of the …