Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

Alzheimer's disease (AD) is the most common cause of dementia and there is currently no
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …

Aims Several factors are known to increase risk for cerebrovascular disease and dementia,
but there is limited evidence on associations between multiple vascular risk factors (VRFs) …

Background The impact of cardiovascular risk burden on cognitive trajectories and brain
structure changes remains unclear. Objectives This study aimed to examine whether …

Background Midlife hypertension confers increased risk for cognitive impairment in late life.
The sensitive period for risk exposure and extent that risk is mediated through amyloid or …

Objective The longitudinal association of the blood biomarkers total tau (t‐tau),
neurofilament light (Nf‐L), and glial fibrillary acidic protein (GFAP) with common sporadic …

Medical imaging provides numerous insights into the subclinical changes that precede
serious diseases such as heart disease and dementia. However, most imaging research …

Importance Up to 40% of dementia cases are potentially preventable; therefore, it is
important to identify high-risk groups to whom resources could be targeted for maximal …

Importance Midlife vascular risk burden is associated with late-life dementia. Less is known
about if and how risk exposure in early adulthood influences late-life brain health. Objective …

Background and Purpose: Functional outcome after stroke may be related to preexisting
brain health. Several imaging markers of brain frailty have been described including brain …