Proteins are the key molecular machines that orchestrate all biological processes of the cell.
Most proteins fold into three-dimensional shapes that are critical for their function. Studying …

Single particle cryo-electron microscopy (cryo-EM) has emerged as the prevailing method
for near-atomic structure determination, shedding light on the important molecular …

A goal of structural biology is to understand how macromolecules carry out their biological
roles by identifying their metastable states, mechanisms of action, pathways leading to …

Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies
motile ciliopathies, a broad class of human diseases. Motile cilia contain myriad different …

There is a growing interest in characterizing the structure and dynamics of large
biomolecular assemblies and their interactions within the cellular environment. A diverse …

Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies
motile ciliopathies, a broad class of human diseases. Motile cilia contain a myriad of different …

Cross-linking mass spectrometry (XL-MS) has become a very useful tool for studying protein
complexes and interactions in living systems. It enables the investigation of many large and …

After the recent double revolutions in structural biology, which include the use of direct
detectors for cryo‐electron microscopy resulting in a significant improvement in the expected …

In modern biological microscopy, the explosion of data volume and complexity highlights the
urgent need for specialised data management support roles. While traditional microscopy …

The intracellular environment is highly crowded (molecular crowding) and differs
significantly from the environment in dilute solutions that we usually use in biochemical …