Etiology of lactic acidosis in malaria

H Possemiers, L Vandermosten… - PLoS …, 2021 - journals.plos.org
Lactic acidosis and hyperlactatemia are common metabolic disturbances in patients with
severe malaria. Lactic acidosis causes physiological adverse effects, which can aggravate …

Metabolic interactions between disease-transmitting vectors and their microbiota

X Song, Z Zhong, L Gao, BL Weiss, J Wang - Trends in Parasitology, 2022 - cell.com
Disease-transmitting vectors are living organisms that pass infectious agents from one
animal/human to another. The epidemiologically important vectors are usually …

Th1-Th2 cross-regulation controls early Leishmania infection in the skin by modulating the size of the permissive monocytic host cell reservoir

MB Carneiro, ME Lopes, LS Hohman, A Romano… - Cell host & …, 2020 - cell.com
The impact of T helper (Th) 1 versus Th2 immunity on intracellular infections is attributed to
classical versus alternative activation of macrophages leading to resistance or susceptibility …

Same, same but different: Exploring Plasmodium cell division during liver stage development

M Roques, A Bindschedler, R Beyeler… - PLoS …, 2023 - journals.plos.org
Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …

[HTML][HTML] Metabolic interactions between Toxoplasma gondii and its host

M Blume, F Seeber - F1000Research, 2018 - ncbi.nlm.nih.gov
Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum
Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can …

Parasite reliance on its host gut microbiota for nutrition and survival

S Zhou, Y Lu, J Chen, Z Pan, L Pang, Y Wang… - The ISME …, 2022 - academic.oup.com
Studying the microbial symbionts of eukaryotic hosts has revealed a range of interactions
that benefit host biology. Most eukaryotes are also infected by parasites that adversely affect …

[HTML][HTML] Lipid and fatty acid metabolism in trypanosomatids

GP de Aquino, MAM Gomes, RK Salinas… - Microbial Cell, 2021 - ncbi.nlm.nih.gov
Trypanosomiases and leishmaniases are neglected tropical diseases that have been
spreading to previously non-affected areas in recent years. Identification of new …

A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission

S Bachmaier, G Giacomelli, E Calvo-Alvarez… - Nature …, 2022 - nature.com
Signaling from ciliary microdomains controls developmental processes in metazoans.
Trypanosome transmission requires development and migration in the tsetse vector …

Linking nutrient sensing and gene expression in Plasmodium falciparum blood‐stage parasites

M Kumar, K Skillman, MT Duraisingh - Molecular microbiology, 2021 - Wiley Online Library
Malaria is one of the most life‐threatening infectious diseases worldwide, caused by
infection of humans with parasites of the genus Plasmodium. The complex life cycle of …

Neofunctionalization of an ancient domain allows parasites to avoid intraspecific competition by manipulating host behaviour

J Chen, G Fang, L Pang, Y Sheng, Q Zhang… - Nature …, 2021 - nature.com
Intraspecific competition is a major force in mediating population dynamics, fuelling
adaptation, and potentially leading to evolutionary diversification. Among the evolutionary …