Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …

Gabapentin (Neurontin®) and pregabalin (Lyrica®) comprise an interesting class of drugs
for chronic pain. These drugs differ structurally and mechanistically from other analgesics …

Gabapentinoids (gabapentin and pregabalin) and antidepressants (tricyclic antidepressants
and serotonin noradrenaline reuptake inhibitors) are often used to treat chronic pain. The …

Gabapentin (GBP) is a first-line therapy for neuropathic pain, but its mechanisms and sites of
action remain uncertain. We investigated GBP-induced modulation of neuropathic pain …

Neuropathic pain is difficult to diagnose in veterinary patients because they are unable to
verbalize their pain. By assuming that neuropathic pain may exist based on the history of …

We calculated in a meta‐analysis the effect size for the reduction of post‐operative pain and
post‐operative analgesic drugs, which can be obtained by the perioperative administration …

BACKGROUND: Moderate to severe pain after total knee arthroplasty often interferes with
postoperative rehabilitation and delays discharge from hospital. The present study …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

Neuropathic pain (NP) often presents with comorbidities, including depression and anxiety.
The amygdala is involved in the processing of mood disorders, fear, and the emotional …