Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Over the past decade, the study of metabolic abnormalities in cancer cells has risen
dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and …

Numerous diseases such as cancer, diabetes, cardiovascular, neurodegenerative diseases,
etc. are linked with overproduction of reactive oxygen species (ROS) and oxidative stress …

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3)
is activated constitutively in a wide array of human cancers. It is an appealing molecular …

Aims: Impaired fatty acid oxidation (FAO) in mitochondria of hepatocytes causes lipid
accumulation and excessive production of reactive oxygen species (ROS) and oxidative …

ABSTRACT Apigenin (4,'5, 7-trihydroxyflavone) is one of the most studied flavonoids with
low toxicity and abundantly present phenolic compound in the plant kingdom. The main …

Apigenin is a flavonoid with antioxidant, anti-inflammatory, and anti-apoptotic activity. In this
study, the potential effects of apigenin on cardiometabolic diseases were investigated in vivo …

There is a growing demand for efficient medical therapies without undesired side effects that
limit their application. Targeted therapies such as deliveries of pharmacologically active …

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Obesity has become a worldwide issue and is accompanied by serious complications.
Western high energy diet has been identified to be a major factor contributing to the current …