During the past 40 years, cytokines and cytokine receptors have been extensively
investigated as either cancer targets or cancer treatments. A strong preclinical rationale …

Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …

Neutrophil extracellular traps (NETs) that are produced in the tumour microenvironment
(TME) have been suggested to play an essential role in the dissemination of metastatic …

The cancer is a serious health problem, which is The cancer death rate (cancer mortality) is
158.3 per 100,000 men and women per year (based on 2013–2017 deaths). Both clinical …

Emerging evidence implicates microbiome involvement in the development of pancreatic
cancer (PaCa). Here, we investigate whether increases in circulating microbial-related …

Stress is an integral part of life. While acute responses to stress are generally regarded as
beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts …

Simple Summary The regulation of hypoxia has recently emerged as having a central impact
in mitochondrial function and dysfunction in various diseases, including the major disorders …

Uncontrolled inflammatory response arising from the tumor microenvironment (TME)
significantly contributes to cancer progression, prompting an investigation and careful …

The NLRP3 inflammasome is a critical component of innate immunity that senses diverse
pathogen-and host-derived molecules. However, its aberrant activation has been associated …

In recent years, the study of NOD-like receptor thermal protein domain associated protein 3
(NLRP3) inflammasome has become a hot topic, especially its role in various tumors. The …