The immune response in multiple sclerosis

S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …

Gut microbiota, leaky gut, and autoimmune diseases

A Christovich, XM Luo - Frontiers in immunology, 2022 - frontiersin.org
With the rising prevalence of autoimmune diseases, the role of the environment, specifically
the gut microbiota, in disease development has grown to be a major area of study. Recent …

An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis

PA Muraro, R Martin, GL Mancardi, R Nicholas… - Nature Reviews …, 2017 - nature.com
Autologous haematopoietic stem cell transplantation (AHSCT) is a multistep procedure that
enables destruction of the immune system and its reconstitution from haematopoietic stem …

Bioactivity of olive oil phenols in neuroprotection

C Angeloni, M Malaguti, MC Barbalace… - International Journal of …, 2017 - mdpi.com
Neurological disorders such as stroke, Alzheimer's and Parkinson's diseases are associated
with high morbidity and mortality, and few or no effective options are available for their …

Gut microbial antigenic mimicry in autoimmunity

N Garabatos, P Santamaria - Frontiers in Immunology, 2022 - frontiersin.org
The gut microbiota plays a major role in the developmental biology and homeostasis of cells
belonging to the adaptive and innate arms of the immune system. Alterations in its …

[HTML][HTML] Immunosenescence in multiple sclerosis: the identification of new therapeutic targets

M Dema, H Eixarch, LM Villar, X Montalban… - Autoimmunity …, 2021 - Elsevier
The number of elderly multiple sclerosis (MS) patients is growing, mainly due to the increase
in the life expectancy of the general population and the availability of effective disease …

Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis

MR von Essen, C Ammitzbøll, RH Hansen… - Brain, 2019 - academic.oup.com
With the discovery that the highly effective anti-CD20 antibody therapies developed to
deplete CD20+ B cells deplete CD20+ T cells equally well, a great interest in the biological …

Neuroinflammation, mast cells, and glia: dangerous liaisons

SD Skaper, L Facci, M Zusso, P Giusti - The Neuroscientist, 2017 - journals.sagepub.com
The perspective of neuroinflammation as an epiphenomenon following neuron damage is
being replaced by the awareness of glia and their importance in neural functions and …