Antimicrobial host defense peptides are produced by all complex organisms as well as
some microbes and have diverse and complex antimicrobial activities. Collectively these …

Entry of herpes simplex virus (HSV) into cells depends upon multiple cell surface receptors
and multiple proteins on the surface of the virion. The cell surface receptors include heparan …

Completely revised and expanded to reflect the latest advancements in the field,
Polysaccharides: Structural Diversity and Functional Versatility, Second Edition outlines …

HSV type-1 and-2 are widespread pathogens producing lifelong infection with multiple
sequelae, including oral, ocular and genital disease. The process of herpesvirus entry is a …

In recent years, many compounds having potent antiviral activity in cell culture have been
detected and some of these compounds are currently undergoing either preclinical or …

Many protein ligands bind to heparan sulfate, which results in their presentation, protection,
oligomerization or conformational activation. Binding depends on the pattern of sulfation and …

Most of the sulfotransferases participating in glycosaminoglycan biosynthesis have now
been identified. Their essential role in generating binding sites for proteins interacting with …

Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for
thousands of years and are present at a high prevalence in the population worldwide. HSV …

Glycosylation is a common and widespread post-translational modification that affects a
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …

Heparan sulfate is one of the most informationally rich biopolymers in Nature. Its simple
sugar backbone is variously modified to different degrees depending on the cellular …