Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …

Accumulating evidence indicates that gut transit time is a key factor in shaping the gut
microbiota composition and activity, which are linked to human health. Both population-wide …

The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

The act of defaecation, although a ubiquitous human experience, requires the coordinated
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …

Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local
diseases, direct access to unique therapeutic targets and the potential for increasing …

Background and aims Gut transit time is a key modulator of host–microbiome interactions,
yet this is often overlooked, partly because reliable methods are typically expensive or …

Abstract Professor Henry Higgins in My Fair Lady said,'Why can'ta woman be more like a
man?'Perhaps unintended, such narration extends to the reality of current drug …

The mammalian virome has been linked to health and disease but our understanding of how
it is structured along the longitudinal axis of the mammalian gastrointestinal tract (GIT) and …

Growing evidence suggests the importance of the small intestinal bacteria in the diet–host–
microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly …

Eating a varied diet is a central tenet of good nutrition. Here, we develop a molecular tool to
quantify human dietary plant diversity by applying DNA metabarcoding with the chloroplast …