The mycobacterial cell envelope—a moving target

CL Dulberger, EJ Rubin, CC Boutte - Nature Reviews Microbiology, 2020 - nature.com
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020 - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Challenging the drug-likeness dogma for new drug discovery in tuberculosis

D Machado, M Girardini, M Viveiros… - Frontiers in …, 2018 - frontiersin.org
The emergence of multi-and extensively drug resistant tuberculosis worldwide poses a great
threat to human health and highlight the need to discover and develop new, effective and …

TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

E Iizasa, Y Chuma, T Uematsu, M Kubota… - Nature …, 2021 - nature.com
Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-
associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family …

[HTML][HTML] Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall

SM Batt, CE Burke, AR Moorey, GS Besra - The Cell Surface, 2020 - Elsevier
Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is the global
leading cause of mortality from an infectious agent. Part of this success relies on the unique …

Mycobacterium tuberculosis metabolism

DF Warner - Cold Spring Harbor perspectives in …, 2015 - perspectivesinmedicine.cshlp.org
Metabolism underpins the physiology and pathogenesis of Mycobacterium tuberculosis.
However, although experimental mycobacteriology has provided key insights into the …

Mycobacterial membranes as actionable targets for lipid-centric therapy in tuberculosis

B Modak, S Girkar, R Narayan… - Journal of Medicinal …, 2022 - ACS Publications
Infectious diseases remain significant health concerns worldwide, and resistance is
particularly common in patients with tuberculosis caused by Mycobacterium tuberculosis …

Activity of lipophilic and hydrophilic drugs against dormant and replicating Mycobacterium tuberculosis

G Piccaro, G Poce, M Biava, F Giannoni… - The journal of …, 2015 - nature.com
Mycobacterium tuberculosis is responsible for about 9 million new tuberculosis (TB) cases
per year and 2 billion latent TB infections (LTBI) worldwide. 1, 2 Most of active TB is owing to …

Trehalose recycling promotes energy-efficient biosynthesis of the mycobacterial cell envelope

AA Pohane, CR Carr, J Garhyan, BM Swarts… - MBio, 2021 - Am Soc Microbiol
The mycomembrane layer of the mycobacterial cell envelope is a barrier to environmental,
immune, and antibiotic insults. There is considerable evidence of mycomembrane plasticity …