Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Neurons in the central nervous system (CNS) are terminally differentiated cells that
gradually lose their ability to support regeneration during maturation due to changes in …

Direct neuronal reprogramming is a promising approach to regenerate neurons from local
glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this …

Cost-efficient library generation by early barcoding has been central in propelling single-cell
RNA sequencing. Here, we optimize and validate prime-seq, an early barcoding bulk RNA …

Despite the therapeutic promise of direct reprogramming, basic principles concerning fate
erasure and the mechanisms to resolve cell identity conflicts remain unclear. To tackle these …

Mitochondria account for essential cellular pathways, from ATP production to nucleotide
metabolism, and their deficits lead to neurological disorders and contribute to the onset of …

Cellular identity is established through complex layers of genetic regulation, forged over a
developmental lifetime. An expanding molecular toolbox is allowing us to manipulate these …

Direct neuronal reprogramming, the process whereby a terminally differentiated cell is
converted into an induced neuron without traversing a pluripotent state, has tremendous …

In vivo direct neuronal reprogramming relies on the implementation of an exogenous
transcriptional program allowing to achieve conversion of a particular neuronal or glial cell …

Neurons in the mammalian central nervous system display an enormous capacity for circuit
formation during development but not later in life. In principle, new circuits could be also …