The role of sex in the genomics of human complex traits

EA Khramtsova, LK Davis, BE Stranger - Nature Reviews Genetics, 2019 - nature.com
Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …

Population genetics of sexual conflict in the genomic era

JE Mank - Nature Reviews Genetics, 2017 - nature.com
Sexual conflict occurs when selection acts in opposing directions on males and females.
Case studies in both vertebrates and invertebrates indicate that sexual conflict maintains …

Quality control and analytic best practices for testing genetic models of sex differences in large populations

EA Khramtsova, MA Wilson, J Martin, SJ Winham… - Cell, 2023 - cell.com
Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …

The genomics of sexual conflict

L Rowe, SF Chenoweth… - The American …, 2018 - journals.uchicago.edu
Sexual dimorphism is a substantial contributor to the diversity observed in nature, extending
from elaborate traits to the expression level of individual genes. Sexual conflict and sexually …

The roles of sexual selection and sexual conflict in shaping patterns of genome and transcriptome variation

NM Tosto, ER Beasley, BBM Wong, JE Mank… - Nature Ecology & …, 2023 - nature.com
Sexual dimorphism is one of the most prevalent, and often the most extreme, examples of
phenotypic variation within species, and arises primarily from genomic variation that is …

The battle of the sexes in humans is highly polygenic

JM Cole, CB Scott, MM Johnson, PR Golightly… - Proceedings of the …, 2024 - pnas.org
Sex-differential selection (SDS), which occurs when the fitness effects of alleles differ
between males and females, can have profound impacts on the maintenance of genetic …

The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics

F Ruzicka, L Dutoit, P Czuppon, CY Jordan… - Evolution …, 2020 - academic.oup.com
Sexually antagonistic (SA) genetic variation—in which alleles favored in one sex are
disfavored in the other—is predicted to be common and has been documented in several …

Temporal genomics in Hawaiian crickets reveals compensatory intragenomic coadaptation during adaptive evolution

X Zhang, M Blaxter, JMD Wood, A Tracey… - Nature …, 2024 - nature.com
Abstract Theory predicts that compensatory genetic changes reduce negative indirect effects
of selected variants during adaptive evolution, but evidence is scarce. Here, we test this in a …

Phenotypic sexual dimorphism is associated with genomic signatures of resolved sexual conflict

AE Wright, TF Rogers, M Fumagalli… - Molecular …, 2019 - Wiley Online Library
Intralocus sexual conflict, where an allele benefits one sex at the expense of the other, has
an important role in shaping genetic diversity of populations through balancing selection …

Sublethal larval exposure to imidacloprid impacts adult behaviour in Drosophila melanogaster

HK Young, SM Denecke, C Robin… - Journal of …, 2020 - academic.oup.com
Pesticides are now chronically found in numerous ecosystems incurring widespread toxic
effects on multiple organisms. For insects, the larvae are very exposed to pesticide pollution …