Phage display derived monoclonal antibodies: from bench to bedside

MA Alfaleh, HO Alsaab, AB Mahmoud… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies

J Zhou, Q Ji, Q Li - Journal of Experimental & Clinical Cancer Research, 2021 - Springer
Cetuximab and panitumumab are monoclonal antibodies (mAbs) against epidermal growth
factor receptor (EGFR) that are effective agents for metastatic colorectal cancer (mCRC) …

Phage display-derived human antibodies in clinical development and therapy

A Frenzel, T Schirrmann, M Hust - MAbs, 2016 - Taylor & Francis
Over the last 3 decades, monoclonal antibodies have become the most important class of
therapeutic biologicals on the market. Development of therapeutic antibodies was …

Drug resistance in colorectal cancer: from mechanism to clinic

Q Wang, X Shen, G Chen, J Du - Cancers, 2022 - mdpi.com
Simple Summary Chemotherapy, radiotherapy and molecularly targeted therapy could
improve the prognosis of colorectal cancer (CRC) patients. Recently, immunotherapy …

[HTML][HTML] Current and emerging therapeutic approaches for colorectal cancer: A comprehensive review

A Kumar, V Gautam, A Sandhu, K Rawat… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) affects 1 in 23 males and 1 in 25 females, making it the third most
common cancer. With roughly 608000 deaths worldwide, CRC accounts for 8% of all cancer …

An overview on display systems (phage, bacterial, and yeast display) for production of anticancer antibodies; advantages and disadvantages

SZB Mahdavi, F Oroojalian, S Eyvazi, M Hejazi… - International Journal of …, 2022 - Elsevier
Antibodies as ideal therapeutic and diagnostic molecules are among the top-selling drugs
providing considerable efficacy in disease treatment, especially in cancer therapy …

[HTML][HTML] Dermatologic toxicity occurring during anti-EGFR monoclonal inhibitor therapy in patients with metastatic colorectal cancer: a systematic review

ME Lacouture, M Anadkat, A Jatoi, T Garawin… - Clinical colorectal …, 2018 - Elsevier
Monoclonal antibody inhibitors of the epidermal growth factor receptor (EGFR) have been
shown to improve outcomes for patients with metastatic colorectal cancer (mCRC) without …

[HTML][HTML] Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress

Y Lu, R Zhang, X Zhang, B Zhang, Q Yao - Biomedicine & …, 2020 - Elsevier
Background and purpose Colorectal cancer is a kind of gastrointestinal tumor with rising
morbidity and mortality. 5-fluorouracil is one of the most effective chemotherapy drugs for the …

[HTML][HTML] Resistance to targeted therapy in metastatic colorectal cancer: Current status and new developments

YL Tang, DD Li, JY Duan, LM Sheng… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most lethal and common malignancies in the world.
Chemotherapy has been the conventional treatment for metastatic CRC (mCRC) patients …

Monoclonal antibodies and chimeric antigen receptor (CAR) T cells in the treatment of colorectal cancer

KT Jin, B Chen, YY Liu, HR Lan, JP Yan - Cancer Cell International, 2021 - Springer
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer deaths worldwide. Besides common therapeutic approaches, such as surgery …