Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding
disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age …

Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs)
associated with characteristic axon degeneration in the optic nerve. Clinically, our only …

Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to
intraocular pressure. Though the precise mechanisms that mediate or transduce this …

Research into treatments for diseases of the CNS has made impressive strides in the past
few decades, but therapeutic options are limited for many patients with CNS disorders …

The Krüppel-like family of transcription factors (KLFs) have been widely studied in
proliferating cells, though very little is known about their role in post-mitotic cells, such as …

Adult mammalian CNS axons generally do not regenerate, creating an obstacle to effective
repair and recovery after neuronal injury. The canonical Wnt/β-catenin signaling pathway is …

Background: Traumatic optic nerve injury is a leading cause of irreversible blindness across
the world and causes progressive visual impairment attributed to the dysfunction and death …

Introduction ELAVL1/HuR is a keystone regulator of gene expression at the
posttranscriptional level, including stress response and homeostasis maintenance. The aim …

Retinal ganglion cell (RGC) death and a failure of axon regeneration contribute to the
profound visual loss experienced by patients after traumatic optic neuropathy (TON), for …

Optic nerve injury is a leading cause of irreversible visual impairment worldwide and can
even cause blindness. Excessive activation of astrocytes has negative effects on the repair …