Vitamin D deficiency is associated with a higher risk of SARS-CoV-2 infection and poor
outcomes of the COVID-19 disease. However, a satisfactory mechanism explaining the …

The concept of targeting cholesterol metabolism to treat cancer has been widely tested in
clinics, but the benefits are modest, calling for a complete understanding of cholesterol …

Pemphigus is a life‐threatening autoimmune bullous disease mediated by anti‐desmoglein
IgG autoantibodies. Pemphigus is mainly classified into three subtypes: pemphigus vulgaris …

The field of sterol and oxysterol biology in lung disease has recently gained attention,
revealing a unique need for sterol uptake and metabolism in the lung. The presence of …

Immunoreceptors have crucial roles in sensing environmental signals and initiating immune
responses to protect the host. Dysregulation of immunoreceptor signalling can therefore …

The mevalonate pathway is an essential metabolic pathway in T cells regulating
development, proliferation, survival, differentiation, and effector functions. The mevalonate …

T cell receptor (TCR) plays a fundamental role in adaptive immunity, and TCR-T cell therapy
holds great promise for treating solid tumors and other diseases. However, there is a …

Chronic spontaneous urticaria (CSU), a mast cell-driven disease, substantially affects the
quality of life. While genetics affect CSU susceptibility and severity, the specific genetic …

Objectives Diabetic cardiomyopathy (DCM) is the leading cause of mortality in type 2
diabetes mellitus (T2DM) patients, with its underlying mechanisms still elusive. This study …

As single‐cell RNA sequencing enables the detailed clustering of T‐cell subpopulations and
facilitates the analysis of T‐cell metabolic states and metabolite dynamics, it has gained …