Targeting cannabinoid receptors: current status and prospects of natural products
D An, S Peigneur, LA Hendrickx, J Tytgat - International journal of …, 2020 - mdpi.com
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …
critical role in numerous human physiological and pathological conditions. Thus …
Pharmacological properties, therapeutic potential and molecular mechanisms of JWH133, a CB2 receptor-selective agonist
The endocannabinoid system has attracted attention as a pharmacological target for several
pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of …
pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of …
Structural basis of selective cannabinoid CB2 receptor activation
X Li, H Chang, J Bouma, LV de Paus… - Nature …, 2023 - nature.com
Abstract Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents
in the clinic. However, their molecular mode-of-action is not fully understood. Here, we report …
in the clinic. However, their molecular mode-of-action is not fully understood. Here, we report …
Expression and Functions of the CB2 Receptor in Human Leukocytes
The cannabinoid CB2 receptor was cloned from the promyeloid cell line HL-60 and is
notably expressed in most, if not all leukocyte types. This relatively restricted localization …
notably expressed in most, if not all leukocyte types. This relatively restricted localization …
A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies
The cannabinoid CB2 receptor (CB2R) is a potential therapeutic target for distinct forms of
tissue injury and inflammatory diseases. To thoroughly investigate the role of CB2R in …
tissue injury and inflammatory diseases. To thoroughly investigate the role of CB2R in …
Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats
Aim Kidney ischemia reperfusion (IR) injury is an important health problem resulting in acute
kidney failure. The oxidative stress and inflammatory process are the underlying …
kidney failure. The oxidative stress and inflammatory process are the underlying …
The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis
Z Zhao, Q Yan, J Xie, Z Liu, F Liu, Y Liu, S Zhou… - Diabetology & metabolic …, 2024 - Springer
Aim Cannabinoid receptors are components of the endocannabinoid system that affect
various physiological functions. We aim to investigate the effect of cannabinoid receptor …
various physiological functions. We aim to investigate the effect of cannabinoid receptor …
The effects of cannabinoids on the kidney
Cannabinoids are a class of drugs derived from the Cannabis plant that are widely used for
the treatment of various medical conditions and recreational use. Common examples …
the treatment of various medical conditions and recreational use. Common examples …
Lack of Cannabinoid Type 2 Promoter Activity in Normal or Injured Kidneys Using a Cnr2-GFP Reporter Mouse
AG Boals, DM Collier, JR Romero… - Cannabis and …, 2024 - liebertpub.com
Introduction: Although cannabinoid type 2 (CB2) receptor activity is known to promote
diverse biological functions in the kidney, published data regarding CB2 receptor protein …
diverse biological functions in the kidney, published data regarding CB2 receptor protein …
Protective effect of fatty acid amide hydrolase inhibitor URB597 and monoacylglycerol lipase inhibitor KML29 on renal ischemia–reperfusion injury via toll-like receptor …
Background Arachidonoyl ethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-
AG) are the most studies endocannabinoids. AEA and 2-AG are degraded by fatty acid …
AG) are the most studies endocannabinoids. AEA and 2-AG are degraded by fatty acid …