In the last decade, single-cell RNA sequencing routinely performed on large numbers of
single cells has greatly advanced our understanding of the underlying heterogeneity of …

Analyzing proteins from single cells by tandem mass spectrometry (MS) has recently
become technically feasible. While such analysis has the potential to accurately quantify …

Single-cell resolution analysis of complex biological tissues is fundamental to capture cell-
state heterogeneity and distinct cellular signaling patterns that remain obscured with …

Major aims of single-cell proteomics include increasing the consistency, sensitivity and
depth of protein quantification, especially for proteins and modifications of biological interest …

The recent technological and computational advances in mass spectrometry-based single-
cell proteomics have pushed the boundaries of sensitivity and throughput. However …

Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

Multiplexed and label-free mass spectrometry–based approaches with single-cell resolution
have attributed surprising heterogeneity to presumed homogenous cell populations. Even …

The field of single-cell omics is rapidly progressing. Although DNA and RNA sequencing-
based methods have dominated the field to date, global proteome profiling has also entered …

The shotgun proteomic analysis is currently the most promising single-cell protein
sequencing technology, however its identification level of~ 1000 proteins per cell is still …

The ability to map a proteomic fingerprint to transcriptomic data would master the
understanding of how gene expression translates into actual phenotype. In contrast to …