Three decades after its introduction as an adjuvant therapeutic option in the management of
selective drug-resistant epilepsy cases (DRE), vagus nerve stimulation (VNS) retains …

Epileptic networks are intimately connected with the autonomic nervous system, as
exemplified by a plethora of ictal (during a seizure) autonomic manifestations, including …

Sudden unexpected death in epilepsy (SUDEP) is generally considered to result from a
seizure, typically convulsive and usually but not always occurring during sleep, followed by …

Novel clinical features may help to define better the individual risk of SUDEP. Potentially
therapeutic strategies including pharmacological modulation of respiratory arrest and …

The risk of dying suddenly and unexpectedly is increased 24‐to 28‐fold among young
people with epilepsy compared to the general population, but the incidence of sudden …

Sudden unexpected death in epilepsy (SUDEP) is the major cause of epilepsy-related
premature mortality which targets preferentially younger people. Its etiology remains …

Prevention of premature death in patients with chronic epilepsy remains a major challenge.
Multiple pathophysiologic factors have been implicated, with intense investigation of …

People with epilepsy have a three‐fold increased risk of dying prematurely, and a significant
proportion is due to sudden cardiac death or acute myocardial infarctions. The causes of …

Recent literature has implicated severe neurologic injuries, such as aneurysmal
subarachnoid hemorrhage, as a cause of cardiac dysfunction, impaired hemodynamic …

Objective The cardiac component of risk for sudden unexpected death in epilepsy (SUDEP)
and alterations in cardiac risk by vagus nerve stimulation (VNS) are not well understood. We …