Despite recent advances in cancer therapeutics, glioblastoma (GBM) remains one of the
most difficult cancers to treat in both the primary and recurrent settings. GBM presents a …

Integrins mediate adhesive interactions between cells and their environment, including
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

Simple Summary Pancreatic cancer (PC) is a highly aggressive malignant tumor with an
extremely poor prognosis. Early diagnosis and treatment are key to improving the survival …

Antibody-based therapeutics have become a major class of therapeutics with over 120
recombinant antibodies approved or under review in the EU or US. This therapeutic class …

Intratumoral hypoxia correlates with metastasis and poor survival in patients with sarcoma.
Using an impedance sensing assay and a zebrafish intravital microinjection model, we …

Simple Summary Novel therapeutic modalities using medical devices have the potential to
deliver effective treatment against the most aggressive form of primary brain tumour …

Glioblastoma (GBM) is the most common adult primary malignant brain tumor and is
associated with a dire prognosis. Despite multi-modality therapies of surgery, radiation, and …

Radiotherapy (RT) is one of the cornerstones in the current treatment paradigm for
glioblastoma (GBM). However, little has changed in the management of GBM since the …

Simple Summary Gastrointestinal (GI) cancers are the leading cancer-related deaths
worldwide. Despite improved survival rates with current treatments, recurrence remains a …