Investigation of Potential Drug Targets Involved in Inflammation Contributing to Alzheimer's Disease Progression

C Sharo, T Zhai, Z Huang - Pharmaceuticals, 2024 - mdpi.com
Alzheimer's disease has become a major public health issue. While extensive research has
been conducted in the last few decades, few drugs have been approved by the FDA to treat …

Drugs targeting APOE4 that regulate beta‐amyloid aggregation in the brain: therapeutic potential for Alzheimer's disease

J Poblano, I Castillo‐Tobías, L Berlanga… - Basic & Clinical …, 2024 - Wiley Online Library
Alzheimer's disease is characterized by progressive cognitive decline, and behavioural and
psychological symptoms of dementia are common. The APOE ε4 allele, a genetic risk factor …

Investigation of potential drug targets for cholesterol regulation to treat Alzheimer's disease

M Passero, T Zhai, Z Huang - International Journal of Environmental …, 2023 - mdpi.com
Despite extensive research and seven approved drugs, the complex interplay of genes,
proteins, and pathways in Alzheimer's disease remains a challenge. This implies the …

[HTML][HTML] Repurposing FDA-Approved Drugs Against Potential Drug Targets Involved in Brain Inflammation Contributing to Alzheimer's Disease

C Sharo, J Zhang, T Zhai, J Bao, A Garcia-Epelboim… - Targets, 2024 - mdpi.com
Alzheimer's disease is a neurodegenerative disease that continues to have a rising number
of cases. While extensive research has been conducted on Alzheimer's disease in the last …