The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …

Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Brain metastasis represents a substantial source of morbidity and mortality in various
cancers, and is characterized by high resistance to chemotherapy. Here we define the role …

Epilepsy and mental retardation limited to females (EFMR) is a disorder with an X-linked
mode of inheritance and an unusual expression pattern. Disorders arising from mutations on …

Cadherin family is classified into classical cadherins, desmosomal cadherins and
protocadherins (PCDHs). Genomic structures distinguish between PCDHs and other …

X-linked diseases typically exhibit more severe phenotypes in males than females. In
contrast, protocadherin 19 (PCDH19) mutations cause epilepsy in heterozygous females but …

Background The epilepsies are a clinically heterogeneous group of neurological disorders.
Despite strong evidence for heritability, genome-wide association studies have had little …

The protocadherins (Pcdhs), which make up the most diverse group within the cadherin
superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including …

Autism spectrum disorders (ASD) are neurodevelopmental disorders with phenotypic and
genetic heterogeneity. Recent studies have reported rare and de novo mutations in ASD, but …