Much remains to be learned about how cancer cells acquire the property of migration, a
prerequisite for invasiveness and metastasis. Loss of p53 functions is assumed to be a …

The tumor-suppressor gene p53 and its downstream genes consist of a complicated gene
network. p53 is a key molecular node in the network, which is activated in response to …

Inhibition of sclerostin with sclerostin antibody (Scl-Ab) has been shown to stimulate bone
formation, decrease bone resorption, and increase bone mass in both animals and humans …

Amyotrophic lateral sclerosis (ALS) is a complex disease characterized by the interplay of
genetic and environmental factors for which, despite decades of intense research, diagnosis …

Caenorhabditis elegans CEP-1 activates germline apoptosis in response to genotoxic
stress, similar to its mammalian counterpart, tumor suppressor p53. In mammals, there are …

In this study, differential gene expression between normal human mammary epithelial cells
and their malignant counterparts (eight well established breast cancer cell lines) was …

ABSTRACT CONTEXT AND OBJECTIVE: Sodium and potassium intake from different food
sources is an important issue regarding cardiovascular physiology. Epidemiological …

A major goal of personalized anti-cancer therapy is to increase the drug effects while
reducing the side effects as much as possible. A novel therapeutic strategy called synthetic …

Abstract Background Maternal Embryonic Leucine Zipper Kinase (MELK) is a
serine/threonine kinase involved in cell cycle, differentiation, proliferation, and apoptosis …

The p53 master regulatory network provides for the stress-responsive direct control of a vast
number of genes in humans that can be grouped into several biological categories including …